DAMPs and NETs in Sepsis
Icahn School of Medicine at Mount Sinai · Feinstein Institute for Medical Research · +1 more institution
Abstract
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host response to pathogens mediated through the interaction of pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs). PRRs are also activated by host nuclear, mitochondrial, and cytosolic proteins, known as damage-associated molecular patterns (DAMPs) that are released from cells during sepsis. Some well described members of the DAMP family are extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1), histones, and adenosine triphosphate (ATP). DAMPs are released from the cell through inflammasome activation or passively…
Citation impact
- FWCI
- 19.50
- Percentile
- 100%
- References
- 201
Authors
4- NDNaomi‐Liza Denning
Icahn School of Medicine at Mount Sinai, Feinstein Institute for Medical Research, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
- MAMonowar AzizCorresponding
Feinstein Institute for Medical Research, Icahn School of Medicine at Mount Sinai
- SDSteven D. Gurien
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell, Feinstein Institute for Medical Research
- PWPing WangCorresponding
Icahn School of Medicine at Mount Sinai, Feinstein Institute for Medical Research, Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
Topics & keywords
- Neutrophil extracellular traps
- HMGB1
- Inflammasome
- Sepsis
- Damp
- Extracellular
- Inflammation
- Innate immune system
- Good health and well-being