Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure
Nankai University · State Key Laboratory of Medicinal Chemical Biology · +5 more institutions
Abstract
Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient ICD to achieve satisfactory cancer immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, and specific ability is reported for effectively inducing focused mitochondrial oxidative stress of cancer cells, which can serve as a much superior ICD inducer to the popularly used ones, including chlorin e6 (Ce6), pheophorbide A, and oxaliplatin. Furthermore, more effective in vivo…
Citation impact
- FWCI
- 29.59
- Percentile
- 100%
- References
- 81
Authors
7- CCChao Chen
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- XNXiang Ni
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- SJShaorui Jia
Nankai University, State Key Laboratory of Medicinal Chemical Biology
- YLYong Liang
Xuzhou Medical College, Second People’s Hospital of Huai’an
- XWXiaoli Wu
Tianjin University
Topics & keywords
- Photosensitizer
- Immunogenicity
- Programmed cell death
- Oxidative stress
- Immunogenic cell death
- In vivo
- Immune system
- Materials science
- Good health and well-being