Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

Pucino, Valentina; Certo, Michelangelo; Bulusu, Vinay; Cucchi, Danilo; Goldmann, Katriona; Pontarini, Elena; Haas, Robert; Smith, Joanne; Headland, Sarah E.; Blighe, Kevin; Ruscica, Massimiliano; Humby, Frances; Lewis, Myles; Kamphorst, Jurre J.; Bombardieri, Michele; Pitzalis, Costantino; Mauro, Claudio

doi:10.1016/j.cmet.2019.10.004

articleCell MetabolismNov 7, 2019HYBRID OA

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

VPValentina Pucino MCMichelangelo Certo VBVinay Bulusu DCDanilo Cucchi KGKatriona Goldmann

Queen Mary University of London · William Harvey Research Institute · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

T cell retention in the inflamed tissue as a consequence of reduced glycolysis and enhanced fatty acid synthesis. Furthermore, antibody-mediated blockade of SLC5A12 ameliorates the disease severity in a murine model of arthritis. Finally, we propose that lactate/SLC5A12-induced metabolic reprogramming is a distinctive feature of lymphoid synovitis in rheumatoid arthritis patients and a potential therapeutic target in chronic inflammatory disorders.

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508

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Topics & keywords

Topics

Keywords

Inflammation
Glycolysis
Arthritis
Rheumatoid arthritis
Immune system
Chemistry
Cancer research
Biology

UN Sustainable Development Goals

Good health and well-being

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