AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma: Am J Transl Res. 2017; 9(2): 507-519
Wuhan University · Kementerian Pendidikan Malaysia · +1 more institution
Abstract
Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. In the present study, human AdCC tissue microarrays including 18 cases of normal salivary gland (NSG), 12 cases of pleomorphic adenoma (PMA) and 72 cases of AdCC were employed for immunohistochemical staining analysis. Results indicated that AGR2, which was remarkably correlated…
Citation impact
- FWCI
- 0.00
- Percentile
- 98%
- References
- 38
Authors
8- SMSi‐Rui Ma
Wuhan University, Kementerian Pendidikan Malaysia
- LMLiang Mao
Wuhan University, Kementerian Pendidikan Malaysia
- WDWeiwei Deng
Wuhan University, Kementerian Pendidikan Malaysia
- YLYicun Li
Wuhan University, Kementerian Pendidikan Malaysia
- LBLin‐Lin Bu
Wuhan University, Kementerian Pendidikan Malaysia
Topics & keywords
- Adenoid cystic carcinoma
- Epithelial–mesenchymal transition
- Antibody-dependent cell-mediated cytotoxicity
- Cancer research
- Head and neck squamous-cell carcinoma
- Metastasis
- Pathology
- Cancer