A Multifunctional Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment
Tianjin University · Marine Biomedical Research Institute of Qingdao · +3 more institutions
Abstract
Abstract Diabetic ulcer is the most common kind of chronic wound worldwide. Though great efforts have been devoted, diabetic ulcer still remains as a challenge that requires constant monitoring and management. In this work, a multifunctional zwitterionic hydrogel is developed to simultaneously detect two fluctuant wound parameters, pH and glucose level, to monitor the diabetic wound status. A pH indicator dye (phenol red) and two glucose sensing enzymes, glucose oxidase (GOx) and horseradish peroxidase (HRP), are encapsulated in the anti‐biofouling and biocompatible zwitterionic poly‐carboxybetaine (PCB) hydrogel matrix. The visible images are collected by a smartphone and transformed into RGB signals to…
Citation impact
- FWCI
- 24.18
- Percentile
- 100%
- References
- 49
Authors
11- YZYingnan Zhu
Tianjin University, Marine Biomedical Research Institute of Qingdao, Collaborative Innovation Center of Chemical Science and Engineering Tianjin
- JZJiamin Zhang
Chinese Academy of Medical Sciences & Peking Union Medical College
- JSJiayin Song
Tianjin University, Marine Biomedical Research Institute of Qingdao, Collaborative Innovation Center of Chemical Science and Engineering Tianjin
- JYJing Yang
Tianjin University, Marine Biomedical Research Institute of Qingdao, Collaborative Innovation Center of Chemical Science and Engineering Tianjin
- ZDZheng Du
Beijing Research Institute of Mechanical and Electrical Technology
Topics & keywords
- Glucose oxidase
- Wound healing
- Biomedical engineering
- Materials science
- Phenol red
- Wound dressing
- pH indicator
- Biofouling
Funding
- IRInnovative Research Group Project of the National Natural Science Foundation of ChinaAward: 21621004
- NNNational Natural Science Foundation of ChinaAwards: 21422605, 21908160, 21621004, 21961132005
- CPChina Postdoctoral Science FoundationAward: 2019M651041
- NSNatural Science Foundation of Tianjin CityAward: 18JCYB‐JC29500