Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Merrill, Michele A. La; Vandenberg, Laura N.; Smith, Martyn T.; Goodson, William H.; Browne, Patience; Patisaul, Heather B.; Guyton, Kathryn Z.; Kortenkamp, Andreas; Cogliano, Vincent James; Woodruff, Tracey J.; Rieswijk, Linda; Sone, Hideko; Korach, Kenneth S.; Gore, Andrea C.; Zeise, Lauren; Zoeller, R. Thomas

doi:10.1038/s41574-019-0273-8

reviewNature Reviews EndocrinologyNov 12, 2019HYBRID OA

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

MAMichele A. La Merrill LNLaura N. Vandenberg MTMartyn T. Smith WHWilliam H. Goodson PBPatience Browne

University of California System · University of California, Davis · +15 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the…

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Topics & keywords

Topics

Keywords

Identification (biology)
Hazard
Key (lock)
Diethylstilbestrol
Risk analysis (engineering)
Hazard analysis
Endocrine system
Computer science

UN Sustainable Development Goals

Good health and well-being

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