Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives

Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global pathogen. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing community-acquired infections, often in healthy individuals. hvKp is carried in the gastrointestinal tract, which contributes to its spread in the community and healthcare settings. First recognized in Asia, hvKp arose as a leading cause of pyogenic liver abscesses. In the decades since, hvKp has spread globally and causes a variety of infections. In addition to liver abscesses, hvKp is distinct from cKp in its ability to metastasize to distant sites, including most commonly the eye, lung and central nervous system (CNS). hvKp has also been…

• BW
  Burroughs Wellcome Fund

  Awards: AI141883,, UL1TR002378, TL1TR002382]
• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases

  Award: AI141883
• HS
  Health Services Research and Development

  Award: I01 BX002788
• NI
  National Institutes of Health
• NC
  National Center for Advancing Translational Sciences

  Award: TL1TR002382 UL1TR002378