articleNucleic Acids ResearchOct 16, 2019GOLD OA

JASPAR 2020: update of the open-access database of transcription factor binding profiles

OFOriol FornésJAJaime A. Castro-MondragónAKAziz KhanRVRobin van der LeeXZXi Zhang

University of British Columbia · BC Children's Hospital · +18 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) for TFs across multiple species in six taxonomic groups. In this 8th release of JASPAR, the CORE collection has been expanded with 245 new PFMs (169 for vertebrates, 42 for plants, 17 for nematodes, 10 for insects, and 7 for fungi), and 156 PFMs were updated (125 for vertebrates, 28 for plants and 3 for insects). These new profiles represent an 18% expansion compared to the previous release. JASPAR 2020 comes with a novel collection of unvalidated TF-binding profiles for which our curators did not find orthogonal supporting evidence in…

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Topics & keywords

Topics
Keywords
  • Biology
  • Transcription factor
  • DNA binding site
  • Computational biology
  • Genetics
  • Database
  • Promoter
  • Gene
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