Epigenetic modifications of histones in cancer
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Abstract
The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications.
Citation impact
574
total citations
- FWCI
- 22.64
- Percentile
- 100%
- References
- 218
Citations per year
Authors
2Topics & keywords
Topics
Keywords
- Histone
- Biology
- Epigenetics
- Computational biology
- Human genetics
- Histone-modifying enzymes
- Epigenesis
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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