LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target. Methods We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with LINRIS (Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with LINRIS inhibited were tested in vitro and in vivo . Results LINRIS was upregulated in CRC tissues from…

• NN
  National Natural Science Foundation of China

  Awards: 201803040019, 81871951, 81802438, 81930065
• SY
  Sun Yat-sen University
• NS
  Natural Science Foundation of Guangdong Province

  Awards: 2014A030312015, 2018B030306049
• SA
  Science and Technology Planning Project of Guangdong Province

  Award: 2019B020227002
• SY
  Sun Yat-sen University Cancer Center