DNA methylation aging clocks: challenges and recommendations
Queen Mary University of London · William Harvey Research Institute · +36 more institutions
Abstract
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important…
Citation impact
- FWCI
- 38.37
- Percentile
- 100%
- References
- 227
Authors
21- CGChristopher G. BellCorresponding
Queen Mary University of London, William Harvey Research Institute
- RLRobert Lowe
Queen Mary University of London
- PDPeter D. AdamsCorresponding
Sanford Burnham Prebys Medical Discovery Institute, Discovery Institute, Cancer Research UK Scotland Institute, University of Glasgow
- ABAndrea BaccarelliCorresponding
Columbia University Irving Medical Center, Columbia University
- SBStephan BeckCorresponding
Cancer Research UK, CRUK Lung Cancer Centre of Excellence, University College London
Topics & keywords
- Biology
- Epigenomics
- DNA methylation
- Epigenetics
- Human genetics
- Evolutionary biology
- Computational biology
- Longevity
- Good health and well-being
Funding
- NSNational Science Foundation
- AAAmerican Association for Cancer ResearchAward: PR0125
- JPJoint Programming Initiative A healthy diet for a healthy lifeAwards: ZonMw 529051021, BB/S020845/1, 529051021
- CRCancer Research UKAwards: C18281/A19169, A19169, C18281, BB/K010867/1
- NINational Institute for Health and Care ResearchAwards: C18281/A19169, BRC369/CN/SB/101310
- DODepartment of Health and Social Care
- DUDiabetes UKAward: 16/0005454
- UOUniversity of BristolAwards: C18281/A19169, MC_UU_12013/5
- DFDeutsche ForschungsgemeinschaftAward: WA 1706/8-1
- NNNational Natural Science Foundation of ChinaAwards: 31771464, 31571359
- ZZonMwAwards: 184.021.007, 529051021
- ARAlzheimer’s Research UKAward: PG2017B-10
- BFBundesministerium für Bildung und Forschung
- NONederlandse Organisatie voor Wetenschappelijk OnderzoekAwards: 184.033.111, 184.021.007, 184.021.007 and 184.033.111, NWO 184.021.007
- DKDeutsche Krebshilfe
- RARWTH Aachen University
- UCUniversity College London Hospitals NHS Foundation Trust
- NINational Institutes of HealthAwards: R01ES014811, ES009089, AG021518, CA214005, RO1MH113930, 184.021.007, AG047745, R01 ES025225, AG031862, RO1AI121226, P30 ES009089, CA100632, CA216265, CA080946, CA207110, AG047200, CA207360, CA221705, RO1MDO1430401, R01 ES027747
- MRMedical Research CouncilAwards: MR/R005176/1, MC_UU_12013, MR/R005176/1, MR/K013807/1, MC_UU_00011/5, MC_UU_12013/5, K013807, MR/K013807/1, R005176
- BABiotechnology and Biological Sciences Research CouncilAwards: BB/K010867/1, BBS/E/B/000C0426, BB/S020845/1, BB/PO28187, BB/R00675X/1, BB/K010867/1, BB/S020845/1, C18281/A19169, ES/N000404/1, BB/R00675X/1, BBS/E/B/000C0425
- EAEconomic and Social Research CouncilAwards: ES/N000404/1, ES/N000404/1, ES/N000498/1, ESN000498/1
- UBUCLH Biomedical Research CentreAward: BRC369/CN/SB/101310
- NINational Institute on AgingAwards: AG031862-12, U34AG051425-01, AG047745, AG031862, AG047200, AG021518, U34AG051425
- NCNational Cancer InstituteAwards: CA080946, CA100632, CA214005, ES009089, CA216265
- NINational Institute of Environmental Health SciencesAwards: R01ES014811, ES009089, R01 ES025225
- IOInstitute of Genetics