RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning

The majority of our human genome transcribes into noncoding RNAs with unknown structures and functions. Obtaining functional clues for noncoding RNAs requires accurate base-pairing or secondary-structure prediction. However, the performance of such predictions by current folding-based algorithms has been stagnated for more than a decade. Here, we propose the use of deep contextual learning for base-pair prediction including those noncanonical and non-nested (pseudoknot) base pairs stabilized by tertiary interactions. Since only [Formula: see text]250 nonredundant, high-resolution RNA structures are available for model training, we utilize transfer learning from a model initially trained with a recent…

• N
  Nvidia
• QC
  Queensland Cyber Infrastructure Foundation
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council