Microglial regional heterogeneity and its role in the brain

Microglia have been recently shown to manifest a very interesting phenotypical heterogeneity across different regions in the mammalian central nervous system (CNS). However, the underlying mechanism and functional meaning of this phenomenon are currently unclear. Baseline diversities of adult microglia in their cell number, cellular and subcellular structures, molecular signature as well as relevant functions have been discovered. But recent transcriptomic studies using bulk RNAseq and single-cell RNAseq have produced conflicting results on region-specific signatures of microglia. It is highly speculative whether such spatial heterogeneity contributes to varying sensitivities of individual microglia to the…

• EC
  European Commission
• ET
  Eesti Teadusagentuur

  Award: MOBTT77
• BM
  Beijing Municipal Science and Technology Commission

  Award: Z171100001017021