preprintWellcome Open ResearchApr 28, 2020GOLD OA

Guidelines for performing Mendelian randomization investigations

SBStephen BurgessGDGeorge Davey SmithNMNeil M DaviesFDFrank DudbridgeDGDipender Gill

University of Cambridge · Erasmus MC · +11 more institutions

PubMed
Indexed incrossrefdatacitedoajpubmed

Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be…

Citation impact

1,350
total citations
FWCI
124.39
Percentile
100%
References
110
Citations per year

Authors

11

Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • Harmonization
  • Scope (computer science)
  • Presentation (obstetrics)
  • Computer science
  • Psychology
  • Medicine
  • Biology
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