Human papillomavirus vaccine against cervical cancer: Opportunity and challenge

Cervical cancer is one of the most common cancers threatening women's health, and the persistent infection of high-risk human papillomavirus (HPV) is closely related to the pathogenesis of cervical cancer and many other cancers. The carcinogenesis is a complex process from precancerous lesion to cancer, which provides an excellent window for clinical prevention, diagnosis, and treatment. However, despite the various preventions and treatments such as HPV screening, prophylactic HPV vaccines, surgery, radiotherapy, and chemotherapy, the disease burden remains heavy worldwide. Currently, three types of prophylactic vaccines, quadrivalent HPV vaccine, bivalent HPV vaccine, and a new nonavalent HPV vaccine, are…

• NN
  National Natural Science Foundation of China

  Awards: 81372804, U1333115, 71373188, 81672085, 30901586, 71871169, U1933120
• NS
  Natural Science Foundation of Hubei Province

  Award: 2019CFA062
• CM
  Chinese Medical Association

  Award: 17020400709