Size‐Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting
Harvard University · Gordon Center for Medical Imaging · +2 more institutions
Abstract
Passive targeting of large nanoparticles by the enhanced permeability and retention (EPR) effect is a crucial concept for solid tumor targeting in cancer nanomedicine. There is, however, a trade-off between the long-term blood circulation of nanoparticles and their nonspecific background tissue uptake. To define this size-dependent EPR effect, near-infrared fluorophore-conjugated polyethylene glycols (PEG-ZW800s; 1-60 kDa) are designed and their biodistribution, pharmacokinetics, and renal clearance are evaluated in tumor-bearing mice. The targeting efficiency of size-variant PEG-ZW800s is investigated in terms of tumor-to-background ratio (TBR). Interestingly, smaller sized PEGs (≤20 kDa, 12 nm) exhibit…
Citation impact
- FWCI
- 16.39
- Percentile
- 100%
- References
- 38
Authors
9- HKHoman Kang
Harvard University, Gordon Center for Medical Imaging, Massachusetts General Hospital
- SRSunghoon Rho
Harvard University, Gordon Center for Medical Imaging, Massachusetts General Hospital
- WRWesley R. Stiles
Harvard University, Gordon Center for Medical Imaging, Massachusetts General Hospital
- SHShuang Hu
Harvard University, Gordon Center for Medical Imaging, Massachusetts General Hospital
- YBYoonji Baek
Harvard University, Gordon Center for Medical Imaging, Massachusetts General Hospital
Topics & keywords
- Materials science
- Nanoparticle
- Electron paramagnetic resonance
- Nanotechnology
- Nuclear magnetic resonance