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articleJournal of Hematology & OncologyDec 9, 2019GOLD OA

RETRACTED ARTICLE: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

DJDan JinJGJiwei GuoYWYan WuJDJing DuLYLijuan Yang

Binzhou Medical University · Binzhou University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Background METTL3 is an RNA methyltransferase that mediates m 6 A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very clear. Methods The expression of mRNA was analyzed by qPCR assays. Protein levels were analyzed by western blotting and immunofluorescent staining. Cellular proliferation was detected by CCK8 assays. Cell migration and invasion were analyzed by wound healing and transwell assays, respectively. Promoter activities and gene transcription were analyzed by luciferase reporter assays. Finally, m 6 A modification was…

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586
total citations
FWCI
34.86
Percentile
100%
References
42
Citations per year

Authors

12

Topics & keywords

Topics
Keywords
  • Gene knockdown
  • Messenger RNA
  • MALAT1
  • Translation (biology)
  • Molecular biology
  • Transcription (linguistics)
  • Cell biology
  • RNA
UN Sustainable Development Goals
  • Good health and well-being
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Funding