Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes

The radical-involved 1,2-difunctionalization of alkenes has developed into a robust tool for preparation of complex organic molecules. Despite significant advances in this area, the catalytic asymmetric version still remains a challenging task mainly due to the difficulty in the stereocontrol of the highly reactive radical intermediates. Recently, owing to the good single-electron transfer ability and coordination with chiral ligands of copper catalysts, remarkable achievements in radical-involved asymmetric alkene difunctionalization have been made via synergistic combination of copper and chiral ligands. This tutorial review highlights the recent progress in copper-catalysed radical-involved asymmetric…

• NN
  National Natural Science Foundation of China

  Awards: 21831002, 21801116, 21722203
• NS
  Natural Science Foundation of Guangdong Province

  Award: 2018A030310083