Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
National Institutes of Natural Sciences · The Graduate University for Advanced Studies, SOKENDAI · +7 more institutions
Abstract
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood-brain barrier (BBB) integrity in this process remains unclear. Using simultaneous in vivo imaging, we demonstrated that systemic inflammation induces CCR5-dependent migration of brain resident microglia to the cerebral vasculature. Vessel-associated microglia initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 and make physical contact with endothelial cells. During sustained inflammation, microglia phagocytose astrocytic end-feet and impair BBB function. Our results show microglia play a dual role in maintaining BBB integrity with…
Citation impact
- FWCI
- 38.10
- Percentile
- 100%
- References
- 72
Authors
13- KHKoichiro HaruwakaCorresponding
National Institutes of Natural Sciences, The Graduate University for Advanced Studies, SOKENDAI, Kobe University
- AIAko Ikegami
Kobe University
- YTYoshihisa Tachibana
Kobe University
- NONobuhiko Ohno
Jichi Medical University, National Institute for Physiological Sciences
- HKHiroyuki Konishi
Nagoya University
Topics & keywords
- Microglia
- Inflammation
- Blood–brain barrier
- Systemic inflammation
- Parenchyma
- Immune system
- Dual role
- Neuroscience
- Good health and well-being