articleJournal of VirologyDec 9, 2019GREEN OA

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

YWYushun WanJSJian ShangSSShihui SunWTWanbo TaiJCJing Chen

University of Minnesota · Institute of Microbiology · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Antibody-dependent enhancement (ADE) of viral entry has been observed for many viruses. It was shown that antibodies target one serotype of viruses but only subneutralize another, leading to ADE of the latter viruses. Here we identify a novel mechanism for ADE: a neutralizing antibody binds to the surface spike protein of coronaviruses like a viral receptor, triggers a conformational change of the spike, and mediates viral entry into IgG Fc receptor-expressing cells through canonical viral-receptor-dependent pathways. We further evaluated how antibody dosages impacted viral entry into cells expressing viral receptor, Fc receptor, or both receptors. This study reveals complex roles of antibodies in viral entry…

Citation impact

702
total citations
FWCI
85.48
Percentile
100%
References
64
Citations per year

Authors

13

Topics & keywords

Topics
Keywords
  • Biology
  • Coronavirus
  • Mechanism (biology)
  • Coronavirus disease 2019 (COVID-19)
  • Virology
  • Antibody
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • 2019-20 coronavirus outbreak
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding