reviewPharmacology & TherapeuticsDec 10, 2019HYBRID OA

Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony

LZLingling ZhangWWWei Wei

Anhui Medical University

PubMed
Indexed incrossrefpubmed

Abstract

As a Traditional Chinese Medicine, Paeonia lactiflora Pallas has been used to treat pain, inflammation and immune disorders for more than 1000 years in China. Total glycoside of paeony (TGP) is extracted from the dried root of Paeonia lactiflora Pallas. Paeoniflorin (Pae) is the major active component of TGP. Our research group has done a lot of work in the pharmacological mechanisms of Pae and found that Pae possessed extensive anti-inflammatory and immune regulatory effects. Pae could inhibit inflammation in the animal models of autoimmune diseases, such as experimental arthritis, psoriatic mice and experimental autoimmune encephalomyelitis, and so on. Pae modulates the functions and activation of immune…

Citation impact

610
total citations
FWCI
51.69
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100%
References
111
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Authors

2

Topics & keywords

Topics
Keywords
  • Paeoniflorin
  • Paeonia lactiflora
  • Immune system
  • Medicine
  • Inflammation
  • Immunology
  • Psoriasis
  • Pharmacology
UN Sustainable Development Goals
  • Good health and well-being
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