reviewInternational Journal of Molecular SciencesDec 11, 2019GOLD OA

Deciphering miRNAs’ Action through miRNA Editing

MCMarta Correia de SousaMGMonika GjorgjievaDDDobrochna DolickaCSCyril SobolewskiMFMichelangelo Foti

University of Geneva

PubMed
Indexed incrossrefpubmed

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. The outcome of a myriad of physiological processes and pathologies, including cancer, cardiovascular and metabolic diseases, relies highly on miRNAs. However, deciphering the precise roles of specific miRNAs in these pathophysiological contexts is challenging due to the high levels of complexity of their actions. Indeed, regulation of mRNA expression by miRNAs is frequently cell/organ specific; highly dependent on the stress and metabolic status of the organism; and often poorly correlated with…

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Authors

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Topics & keywords

Topics
Keywords
  • microRNA
  • Biology
  • Epigenetics
  • Regulation of gene expression
  • Gene expression
  • RNA editing
  • Computational biology
  • Non-coding RNA
UN Sustainable Development Goals
  • Good health and well-being
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