Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

It is now becoming well established that vesicles are released from a broad range of cell types and are involved in cell-to-cell communication, both in physiological and pathological conditions. Once outside the cell, these vesicles are termed extracellular vesicles (EVs). The cellular origin (cell type), subcellular origin (through the endosomal pathway or pinched from the cell membrane) and content (what proteins, glycoproteins, lipids, nucleic acids, metabolites) are transported by the EVs, and their size, all seem to be contributing factors to their overall heterogeneity. Efforts are being invested into attempting to block the release of subpopulations of EVs or, indeed, all EVs. Some such studies are…

• IR
  Irish Research Council for Science, Engineering and Technology

  Award: IRCLA/2019/49
• IR
  Irish Research Council

  Award: IRCLA/2019/49
• H2
  Horizon 2020 Framework Programme

  Award: 722148