Cardiac monocytes and macrophages after myocardial infarction
Indexed incrossrefpubmed
Abstract
Improvements in early interventions after acute myocardial infarction (AMI), notably, the increased use of timely reperfusion therapy, have increased survival dramatically in recent decades. Despite this, maladaptive ventricular remodelling and subsequent heart failure (HF) following AMI remain a significant clinical challenge, particularly because several pre-clinical strategies to attenuate remodelling have failed to translate into clinical practice. Monocytes and macrophages, pleiotropic cells of the innate immune system, are integral in both the initial inflammatory response to injury and subsequent wound healing in many tissues, including the heart. However, maladaptive immune cell behaviour contributes…
Citation impact
590
total citations
- FWCI
- 31.71
- Percentile
- 100%
- References
- 88
Citations per year
Authors
4Topics & keywords
Topics
Keywords
- Macrophage
- Monocyte
- Myocardial infarction
- Immune system
- Inflammation
- Innate immune system
- Medicine
- Ventricular remodeling
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.