Intracellular sensing of viral genomes and viral evasion
Chungnam National University · Komipharm International (South Korea)
Abstract
During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive immune responses against the virus. Recent studies show that signal transduction pathways activated by sensing proteins are positively or negatively regulated by many modulators to maintain host immune homeostasis. However, viruses have evolved several strategies to counteract/evade host immune reactions. These systems involve viral proteins that interact with host sensor proteins and prevent them from detecting the viral genome or from initiating immune signaling.…
Citation impact
- FWCI
- 28.16
- Percentile
- 100%
- References
- 173
Authors
3Topics & keywords
- Biology
- Immune system
- Innate immune system
- Cytosol
- Intracellular
- Cell biology
- Virus
- Evasion (ethics)