Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

Harrell, Carl Randall; Jovičić, Nemanja; Djonov, Valentin; Arsenijević, Nebojša; Volarević, Vladislav

doi:10.3390/cells8121605

reviewCellsDec 11, 2019GOLD OA

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

CRCarl Randall Harrell NJNemanja Jovičić VDValentin Djonov NANebojša Arsenijević VVVladislav Volarević

University of Kragujevac · University of Bern

PubMed

Indexed incrossrefdatacitedoajpubmed

Abstract

There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) that regulate phenotype, function and homing of immune cells. In this review article we emphasized current knowledge regarding molecular mechanisms responsible for the therapeutic effects of MSC-EVs in attenuation of autoimmune and inflammatory diseases. We described the disease-specific cellular targets of MSC-EVs and defined MSC-sourced molecules, which were responsible for MSC-EV-based…

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775

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Topics & keywords

Topics

Keywords

Mesenchymal stem cell
Microvesicles
Immune system
Cell biology
Exosome
Biology
Chemokine
Stem cell

UN Sustainable Development Goals

Good health and well-being

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