GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Kraft, Vanessa A. N.; Bezjian, Carla T.; Pfeiffer, Susanne; Ringelstetter, Larissa; Müller, Constanze; Zandkarimi, Fereshteh; Merl‐Pham, Juliane; Bao, Xuanwen; Anastasov, Nataša; Kössl, Johanna; Brandner, Stefanie; Daniels, Jacob D.; Schmitt‐Kopplin, Philippe; Hauck, Stefanie M.; Stockwell, Brent R.; Hadian, Kamyar; Schick, Joel

doi:10.1021/acscentsci.9b01063

articleACS Central ScienceDec 27, 2019DIAMOND OA

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

VAVanessa A. N. Kraft CTCarla T. Bezjian SPSusanne Pfeiffer LRLarissa Ringelstetter CMConstanze Müller

Helmholtz Zentrum München · Columbia University

PubMed

Indexed incrossrefdoajpubmed

Abstract

, and peroxidation of unusual phospholipids with two polyunsaturated fatty acyl tails. This demonstrates a unique mechanism of ferroptosis protection that is independent of the GPX4/glutathione system.

Citation impact

1,190

total citations

FWCI: 50.30
Percentile: 100%
References: 51

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Authors

17

Topics & keywords

Topics

Keywords

Tetrahydrobiopterin
GPX4
Programmed cell death
Glutathione
Lipid peroxidation
Cell biology
GTP cyclohydrolase I
Chemistry

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

NC
National Cancer Institute
Awards: P01CA087497, R35CA209896