Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

Joie, Renaud La; Visani, Adrienne; Baker, Suzanne L.; Brown, Jesse A.; Bourakova, Viktoriya; Cha, Jungho; Chaudhary, Kiran; Edwards, Lauren; Iaccarino, Leonardo; Janabi, Mustafa; Lesman‐Segev, Orit H.; Miller, Zachary; Perry, David C.; O’Neil, James P.; Pham, Julie; Rojas, Julio C.; Rosen, Howard J.; Seeley, William W.; Tsai, Richard; Miller, Bruce L.; Jagust, William J.; Rabinovici, Gil D.

doi:10.1126/scitranslmed.aau5732

articleScience Translational MedicineJan 1, 2020GREEN OA

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

RLRenaud La Joie AVAdrienne Visani SLSuzanne L. Baker JAJesse A. Brown VBViktoriya Bourakova

University of California, San Francisco · Lawrence Berkeley National Laboratory · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Β-Amyloid plaques and tau-containing neurofibrillary tangles are the two neuropathological hallmarks of Alzheimer's disease (AD) and are thought to play crucial roles in a neurodegenerative cascade leading to dementia. Both lesions can now be visualized in vivo using positron emission tomography (PET) radiotracers, opening new opportunities to study disease mechanisms and improve patients' diagnostic and prognostic evaluation. In a group of 32 patients at early symptomatic AD stages, we tested whether β-amyloid and tau-PET could predict subsequent brain atrophy measured using longitudinal magnetic resonance imaging acquired at the time of PET and 15 months later. Quantitative analyses showed that the global…

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Topics & keywords

Topics

Keywords

Atrophy
Medicine
Prospective cohort study
Alzheimer's disease
Disease
Magnetic resonance imaging
Pathology
Degenerative disease

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