Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Abstract Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O 2 molecules to produce highly cytotoxic singlet oxygen ( 1 O 2 ) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn 3 [Co(CN) 6 ] 2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The…

• NR
  National Research Foundation
• NR
  National Research Foundation Singapore

  Awards: NRF-NRFI2018-03, NRFI2018-03
• NN
  National Natural Science Foundation of China

  Awards: 31471268, NRF-NRFI2018-03
• NS
  National Synchrotron Radiation Laboratory