N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
Howard Hughes Medical Institute · University of Chicago · +7 more institutions
Abstract
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) in mammalian cells. Disruption of m 6 A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m 6 A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription. Science , this issue p. 580
Citation impact
- FWCI
- 35.34
- Percentile
- 100%
- References
- 45
Authors
13- JLJun LiuCorresponding
Howard Hughes Medical Institute, University of Chicago
- XDXiaoyang DouCorresponding
Howard Hughes Medical Institute, University of Chicago
- CCChuanyuan Chen
Chinese Academy of Sciences, Beijing Institute of Genomics, Shanghai East Hospital, University of Chinese Academy of Sciences
- CCChuanyuan ChenCorresponding
Chinese Academy of Sciences, Beijing Institute of Genomics, Shanghai East Hospital, University of Chinese Academy of Sciences
- CCChuan Chen
Howard Hughes Medical Institute, Chinese Academy of Sciences, Beijing Institute of Genomics, University of Chicago, Shanghai East Hospital, University of Chinese Academy of Sciences
Topics & keywords
- Chromatin
- Transcription (linguistics)
- RNA
- Biology
- Cell biology
- Gene
- Genetics
- Molecular biology