Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
University of California, San Francisco · Chinese Academy of Medical Sciences & Peking Union Medical College · +1 more institution
Abstract
Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG). Here we demonstrate a critical contribution of DRG macrophages, but not those at the nerve injury site, to both the initiation and maintenance of the mechanical hypersensitivity that characterizes the neuropathic pain phenotype. In contrast to the reported sexual dimorphism in the microglial contribution to neuropathic pain, depletion of DRG macrophages reduces nerve injury-induced mechanical hypersensitivity and expansion of DRG macrophages in both male and female mice. However, fewer macrophages are induced…
Citation impact
- FWCI
- 37.49
- Percentile
- 100%
- References
- 61
Authors
9- XYXiaobing YuCorresponding
University of California, San Francisco
- HLHongju Liu
University of California, San Francisco, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
- KHKatherine Hamel
University of California, San Francisco
- MMMaelig Morvan
University of California, San Francisco
- SYStephen Yu
University of California, San Francisco
Topics & keywords
- Neuropathic pain
- Dorsal root ganglion
- Peripheral nerve injury
- Nerve injury
- Microglia
- Sensory system
- Medicine
- Neuroscience
- Good health and well-being