articleProceedings of the National Academy of SciencesJan 13, 2020HYBRID OA

A scalable pipeline for designing reconfigurable organisms

University of Vermont · Tufts University · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Living systems are more robust, diverse, complex, and supportive of human life than any technology yet created. However, our ability to create novel lifeforms is currently limited to varying existing organisms or bioengineering organoids in vitro. Here we show a scalable pipeline for creating functional novel lifeforms: AI methods automatically design diverse candidate lifeforms in silico to perform some desired function, and transferable designs are then created using a cell-based construction toolkit to realize living systems with the predicted behaviors. Although some steps in this pipeline still require manual intervention, complete automation in future would pave the way to designing and deploying unique,…

Citation impact

467
total citations
FWCI
39.60
Percentile
100%
References
40
Citations per year

Authors

4

Topics & keywords

Keywords
  • Bespoke
  • Computer science
  • Scalability
  • Pipeline (software)
  • Automation
  • Function (biology)
  • Systems engineering
  • Software engineering
UN Sustainable Development Goals
  • Responsible consumption and production
No related works found for this paper.

Funding