Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer
Henan University of Science and Technology · Zhongda Hospital Southeast University · +3 more institutions
Abstract
Abstract Background 5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC. Recently, microRNAs (miRNAs) have been established as a means of reversing the dilemma by regulating signaling pathways involved in initiation and progression of CRC. However, how to safely and effectively deliver miRNA to target cells becomes a main challenge. Results In this study, Engineered exosomes were exploited to simultaneously deliver an anticancer drug 5-FU and miR-21 inhibitor oligonucleotide (miR-21i) to Her2 expressing cancer cells. Purified engineered exosomes from the donor cells loaded with 5-FU and miR-21i via…
Citation impact
- FWCI
- 33.17
- Percentile
- 100%
- References
- 49
Authors
9- GLGaofeng LiangCorresponding
Henan University of Science and Technology, Zhongda Hospital Southeast University
- YZYanliang Zhu
Zhongda Hospital Southeast University, State Key Laboratory of Digital Medical Engineering, Southeast University
- DJDoulathunnisa Jaffar Ali
State Key Laboratory of Digital Medical Engineering, Southeast University
- TTTian Tian
State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing Medical University
- HXHuantian Xu
State Key Laboratory of Digital Medical Engineering, Southeast University
Topics & keywords
- Microvesicles
- Exosome
- Cancer research
- microRNA
- Colorectal cancer
- Drug delivery
- Cancer
- Apoptosis
- Good health and well-being