Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug-microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications,…

• RG
  Rijksuniversiteit Groningen
• UM
  Universiteit Maastricht
• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Awards: 864.13.013, 016.178.056, NWO SPI 92-266, SPI 92-266, 016.136.308
• MU
  Maastricht Universitair Medisch Centrum
• UM
  Universitair Medisch Centrum Groningen
• ML
  Maag Lever Darm Stichting

  Award: D16-14