articleNatureJan 15, 2020HYBRID OA

B cells are associated with survival and immunotherapy response in sarcoma

FPFlorent PetitprezADAurélien de ReynièsEZEmily Z. KeungTWTom Wei‐Wu ChenCSCheng‐Ming Sun

Université Paris Cité · Centre de Recherche des Cordeliers · +17 more institutions

PubMed
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Abstract

Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation of patients with different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade vary widely3,4. To explain this clinical variability, here we study gene expression profiles in 608 tumours across subtypes of soft-tissue sarcoma. We establish an immune-based classification on the basis of the composition of the tumour microenvironment and identify five distinct phenotypes: immune-low (A and B), immune-high (D and E), and highly vascularized (C) groups. In situ analysis of an independent validation cohort shows that class E was characterized by…

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Topics & keywords

Topics
Keywords
  • Pembrolizumab
  • Immune system
  • CD8
  • Sarcoma
  • Context (archaeology)
  • Soft tissue sarcoma
  • Cytotoxic T cell
  • Immunotherapy
UN Sustainable Development Goals
  • Peace, Justice and strong institutions
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