The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

Microtubules are cytoskeletal structures involved in stability, transport and organization in the cell. The building blocks, the α- and β-tubulin heterodimers, form protofilaments that associate laterally into the hollow microtubule. Microtubule also exists as highly stable doublet microtubules in the cilia where stability is needed for ciliary beating and function. The doublet microtubule maintains its stability through interactions at its inner and outer junctions where its A- and B-tubules meet. Here, using cryo-electron microscopy, bioinformatics and mass spectrometry of the doublets of Chlamydomonas reinhardtii and Tetrahymena thermophila, we identified two new inner junction proteins, FAP276 and FAP106,…

• CI
  Canadian Institute for Advanced Research
• CR
  Canada Research Chairs

  Award: 950-229792
• CI
  Canadian Institutes of Health Research

  Award: PJT-156354
• NS
  Natural Sciences and Engineering Research Council of Canada

  Awards: RGPIN-2016-04954, RGPIN-2018-04813, RGPIN-2017-04649
• JS
  Japan Society for the Promotion of Science