M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

Abstract Background Long non-coding RNAs (lncRNAs) possess significant regulatory functions in multiple biological and pathological processes, especially in cancer. Dysregulated lncRNAs in hepatocellular carcinoma (HCC) and their therapeutic applications remain unclear. Methods Differentially expressed lncRNA profile in HCC was constructed using TCGA data. LINC00958 expression level was examined in HCC cell lines and tissues. Univariate and multivariate analyses were performed to demonstrate the prognostic value of LINC00958. Loss-of-function and gain-of-function experiments were used to assess the effects of LINC00958 on cell proliferation, motility, and lipogenesis. Patient-derived xenograft model was…

• NN
  National Natural Science Foundation of China

  Awards: ZDRCA2016028, No. 81870448, 81521004, and 81572262, 81870448, 81572262, 81521004, BRA2016516
• GO
  Government of Jiangsu Province

  Award: QNRC2016580
• NM
  Nanjing Medical University

  Awards: SKLRM-K201706, 2017NJMUCX005
• WM
  Wannan Medical College
• JP
  Jiangsu Province's Key Provincial Talents Program

  Award: No. ZDRCA2016028
• NS
  Natural Science Foundation of Anhui Province

  Award: 1908085QH332