Size-Tunable Strategies for a Tumor Targeted Drug Delivery System
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Abstract
Nanoparticles have been widely used in tumor targeted drug delivery, while the antitumor effects are not always satisfactory due to the limited penetration and retention. As we all know, there is a paradox that nanoparticles with large sizes tend to distribute around tumor blood vessels rather than penetrate into tumor parenchyma, while smaller sizes can penetrate deeply but with poor tumor retention. In recent days, an intelligent, size-tunable strategy provided a solution to determine the size problem of nanoparticles and exhibited good application prospects. In this review, we summarize series of stimuli-induced aggregation and shrinkage strategies for tumor targeted drug delivery, which can significantly…
Citation impact
478
total citations
- FWCI
- 21.66
- Percentile
- 100%
- References
- 182
Citations per year
Authors
4Topics & keywords
Topics
Keywords
- Nanotechnology
- Drug delivery
- Nanoparticle
- Stacking
- Targeted drug delivery
- Materials science
- Chemistry
- Organic chemistry
UN Sustainable Development Goals
- Good health and well-being
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