Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
Sun Yat-sen University · The First Affiliated Hospital, Sun Yat-sen University · +2 more institutions
Abstract
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms…
Citation impact
- FWCI
- 44.36
- Percentile
- 100%
- References
- 294
Authors
4- XFXingliang Fan
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University
- YZYuelin Zhang
Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital
- XLXin Li
Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital
- QFQing‐Ling FuCorresponding
Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University
Topics & keywords
- Mesenchymal stem cell
- Regenerative medicine
- Immune system
- Paracrine signalling
- Biology
- Regeneration (biology)
- Cell biology
- Cell
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: 81471832, 81970863, 81900919, 2015B020225001, 81671882, 81770984
- NSNatural Science Foundation of Guangdong ProvinceAwards: 2017A030313105, 2015B020225001, 81671882, 2016A030308017, 2014A030313051
- GSGuangdong Science and Technology DepartmentAward: 2015B020225001
- MSMedical Science and Technology Foundation of Guangdong ProvinceAward: 2015B020225001