Alloying design of biodegradable zinc as promising bone implants for load-bearing applications
Peking University · Shanghai Ninth People's Hospital · +3 more institutions
Abstract
Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies. Li exhibits the most effective strengthening role in Zn, followed by Mg. Alloying leads to accelerated degradation, but adequate mechanical integrity can be expected for Zn alloys when considering bone fracture healing. Adding elements Mg, Ca, Sr and Li into Zn can improve the cytocompatibility, osteogenesis, and osseointegration. Further optimization of the ternary Zn-Li alloy…
Citation impact
- FWCI
- 29.92
- Percentile
- 100%
- References
- 69
Authors
9Topics & keywords
- Materials science
- Ultimate tensile strength
- Zinc
- Alloy
- Osseointegration
- Metallurgy
- Implant
- Surgery