Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy

Human papillomavirus (HPV)-induced cervical cancer is a major health issue among women from the poorly/under-developed sectors of the world. It accounts for a high mortality rate, because of its late diagnosis and poor prognosis. Initial establishment and subsequent progression of this form of cancer is completely dependent on two major oncogenes E6 and E7, which is expressed constitutively leading to tumorigenesis. Thus, manipulation of these genes represent the most successful form of cervical cancer therapy. In the present article information on structural, functional and clinical dimensions of E6 and E7 activity have been reviewed. The genome organisation and protein structure of E6 and E7 have been…

• UG
  University Grants Commission
• UO
  University of Calcutta