reviewJournal of Molecular MedicineJan 22, 2020HYBRID OA

Clinical implications of intratumor heterogeneity: challenges and opportunities

SRSantiago Ramón y CajalMSMarta SeséCCClaudia CapdevilaTATrond AasenLDLeticia De Mattos‐Arruda

Hebron University · Universitat Autònoma de Barcelona · +7 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. Functionally, heterogeneity provides tumors with significant adaptability. This ranges from mutual beneficial cooperation between cells, which nurture features such as growth and metastasis, to the narrow escape and survival of clonal cell populations that have adapted to thrive under specific conditions such as hypoxia or chemotherapy. These dynamic intercellular interplays are guided by a Darwinian…

Citation impact

510
total citations
FWCI
21.36
Percentile
100%
References
211
Citations per year

Authors

8

Topics & keywords

Topics
Keywords
  • Epigenetics
  • Biology
  • Genetic heterogeneity
  • Tumor heterogeneity
  • Phenotype
  • Tumor microenvironment
  • Metastasis
  • Adaptability
UN Sustainable Development Goals
  • Partnerships for the goals
No related works found for this paper.

Funding