Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Institute for Experimental Endocrinology and Oncology · National Research Council · +2 more institutions
Abstract
Obesity is one of the major health burdens of the 21st century as it contributes to the growing prevalence of its related comorbidities, including insulin resistance and type 2 diabetes. Growing evidence suggests a critical role for overnutrition in the development of low-grade inflammation. Specifically, chronic inflammation in adipose tissue is considered a crucial risk factor for the development of insulin resistance and type 2 diabetes in obese individuals. The triggers for adipose tissue inflammation are still poorly defined. However, obesity-induced adipose tissue expansion provides a plethora of intrinsic signals (e.g., adipocyte death, hypoxia, and mechanical stress) capable of initiating the…
Citation impact
- FWCI
- 82.95
- Percentile
- 100%
- References
- 276
Authors
7- FZFederica Zatterale
Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- MLMichele Longo
Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- JNJamal Naderi
University of Campania "Luigi Vanvitelli", Institute for Experimental Endocrinology and Oncology, National Research Council
- GAGregory Alexander Raciti
Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
- ADAntonella Desiderio
Institute for Experimental Endocrinology and Oncology, National Research Council, University of Naples Federico II
Topics & keywords
- Adipose tissue
- Insulin resistance
- Adipose tissue macrophages
- Inflammation
- Internal medicine
- Endocrinology
- Immune system
- Type 2 diabetes
- Zero hunger