articleJournal of Proteome ResearchJan 27, 2020GREEN OA

Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics

KJKendra J. AdamsBPBrian PrattNBNeelanjan BoseLGLaura G. DuboisLSLisa St. John‐Williams

Duke University · University of Washington · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Vendor-independent software tools for quantification of small molecules and metabolites are lacking, especially for targeted analysis workflows. Skyline is a freely available, open-source software tool for targeted quantitative mass spectrometry method development and data processing with a 10 year history supporting six major instrument vendors. Designed initially for proteomics analysis, we describe the expansion of Skyline to data for small molecule analysis, including selected reaction monitoring, high-resolution mass spectrometry, and calibrated quantification. This fundamental expansion of Skyline from a peptide-sequence-centric tool to a molecule-centric tool makes it agnostic to the source of the…

Citation impact

611
total citations
FWCI
24.17
Percentile
100%
References
53
Citations per year

Authors

16

Topics & keywords

Topics
Keywords
  • Skyline
  • Computer science
  • Workflow
  • Software
  • Data mining
  • Visualization
  • Quantitative proteomics
  • Proteomics
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
No related works found for this paper.

Funding