Ferroptosis: past, present and future

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury,…

• CM
  Capital Medical University

  Awards: 1192070312, Z191100006619038, No.1192070312
• BM
  Beijing Municipal Science and Technology Commission

  Award: No. Z191100006619038
• NN
  National Natural Science Foundation of China-Yunnan Joint Fund

  Award: No.81770639