articleScienceJan 31, 2020GREEN OA

Cerebrospinal fluid influx drives acute ischemic tissue swelling

HMHumberto MestreTDTing DuAMAmanda M. SweeneyGLGuojun LiuAJAndrew J. Samson

University of Rochester Medical Center · China Medical University · +8 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular…

Citation impact

481
total citations
FWCI
31.67
Percentile
100%
References
83
Citations per year

Authors

23

Topics & keywords

Topics
Keywords
  • Cerebrospinal fluid
  • Swelling
  • Stroke (engine)
  • Edema
  • Medicine
  • Brain swelling
  • Depolarization
  • Neurodegeneration
UN Sustainable Development Goals
  • Clean water and sanitation
No related works found for this paper.

Funding