Microglia Heterogeneity in the Single-Cell Era

Microglia are resident immune cells in the central nervous system (CNS) that are capable of carrying out prominent and various functions during development and adulthood under both homeostatic and disease conditions. Although microglia are traditionally thought to be heterogeneous populations, which potentially allows them to achieve a wide range of responses to environmental changes for the maintenance of CNS homeostasis, a lack of unbiased and high-throughput methods to assess microglia heterogeneity has prevented the study of spatially and temporally distributed microglia subsets. The recent emergence of novel single-cell techniques, such as cytometry by time-of-flight mass spectrometry (CyTOF) and…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: SFB1160, 390939984, SFB 992, EXC-2189
• BF
  Bundesministerium für Bildung und Forschung
• KF
  Kanae Foundation for the Promotion of Medical Science
• RM
  Roman, Marga und Mareille Sobek Stiftung
• JS
  Japan Society for the Promotion of Science