The evolutionary history of 2,658 cancers

Abstract Cancer develops through a process of somatic evolution 1,2 . Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes 3 . Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) 4 , we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number…

• LK
  Li Ka Shing Foundation
• WT
  Wellcome Trust

  Award: FC001202
• FC
  Francis Crick Institute

  Award: FC001202
• CR
  Cancer Research UK

  Awards: A17197, C14303, C14303/A17197, FC001202, C14303/A17197 and A19274, A19274
• UO
  University of Cambridge
• EC
  European Commission

  Awards: 703594, 747852
• FW
  Fonds Wetenschappelijk Onderzoek
• HW
  Hutchison Whampoa Limited
• NI
  National Institutes of Health

  Awards: R01 CA132897, CA016672, P30 CA016672, NIH R01
• NS
  Natural Sciences and Engineering Research Council of Canada
• MR
  Medical Research Council

  Awards: FC001202, MR/L016311/1, MR/L016311/1
• NI
  National Institute of Mental Health
• NC
  National Cancer Institute

  Awards: P30 CA016672, CA016672, R01 CA132897, NIH R01 CA132897