reviewSignal Transduction and Targeted TherapyFeb 7, 2020GOLD OA

Targeting cancer stem cell pathways for cancer therapy

LYLiqun YangPSPengfei ShiGZGaichao ZhaoJXJie XuWPWen Peng

Southwest University · State Key Laboratory of Silkworm Genomic Biology · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. The biological activities of CSCs are regulated by several pluripotent transcription factors, such as OCT4, Sox2, Nanog, KLF4, and MYC. In addition, many intracellular signaling pathways, such as Wnt, NF-κB (nuclear factor-κB), Notch, Hedgehog, JAK-STAT (Janus kinase/signal transducers and activators of transcription), PI3K/AKT/mTOR (phosphoinositide…

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Authors

11

Topics & keywords

Topics
Keywords
  • Cancer stem cell
  • Cancer research
  • SOX2
  • Biology
  • Stem cell
  • Wnt signaling pathway
  • Homeobox protein NANOG
  • PI3K/AKT/mTOR pathway
UN Sustainable Development Goals
  • Good health and well-being
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