Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001
Mayo Clinic in Arizona · Northwestern Medicine · +26 more institutions
Abstract
PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain radiotherapy (WBRT) is hypothesized to preserve cognition. METHODS This phase III trial enrolled adult patients with brain metastases to HA-WBRT plus memantine or WBRT plus memantine. The primary end point was time to cognitive function failure, defined as decline using the reliable change index on at least one of the cognitive tests. Secondary end points included overall survival (OS), intracranial progression-free survival (PFS), toxicity, and patient-reported symptom burden. RESULTS Between July…
Citation impact
- FWCI
- 63.78
- Percentile
- 100%
- References
- 35
Authors
31Topics & keywords
- Medicine
- Memantine
- Oncology
- Whole brain radiotherapy
- Internal medicine
- Radiation therapy
- Glioblastoma
- Radiation oncology
- Quality Education